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Immune Active

Immune Active

Regular price R 990.00
Regular price R 1,100.00 Sale price R 990.00
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If you're only ordering Metagenics, please order from: (no 'www') to save less 10% on all Metagenics products always! 

Featuring Quercetin, NAC, Zinc, EGCG & Vitamin C 

Immune Active provides high potency vitamin C and zinc and features quercetin, NAC and EGCG to help support a healthy immune response and promote antioxidant processes.

Metagenics designed this all-in-1 immune formula based on emerging COVID research and is safe to take through The 4 Phases of COVID. You would just need to add vitamin D3 and possibly vitamin A.

While Immune Active has been designed to be safe when with comorbidities, please always check with your healthcare practitioner before starting any new supplement. 


This product is useful in the following phases of COVID:

Immune Active is useful and safe to use in all The 4 Phases of COVID. It has also been designed to be taken by people with comorbidities but always check with your doctor before starting any new supplement, especially if you have a comorbidity or are on medication. 

  • Prevention Phase: Support is focused on immune surveillance efficiency and reduction of baseline levels of inflammation, to improve outcomes if the patient becomes infected,

  • Infection Phase: Support emphasizes immune activity against infection,

  • Escalating Inflammation Phase:- support is focused on anti-inflammatory measures.

  • Recovery Phase: Support is focused on resolving inflammation, inhibiting fibrosis and other forms of tissue damage, curtailing losses of function, and restoring and reoptimizing function. People have been observed to relapse into the Escalating Inflammation Phase, so it is essential for clinical surveillance to continue well into what may appear to be the Recovery Phase.


    Immune Active and Ultra Potent-C complement each other and are safe to take through The 4 Phases of COVID.

    Immune Active and ImmuCore® (Ultra Potent-C + medicinal mushrooms) also complement each other. While Immune Active is safe through The 4 Phases of COVIDImmuCore® should only be taken in the Prevention and Infection Phase.

    The COVID Inflammasome

    By now, you've heard about the 'cytokine storm' in COVID, where the SarsCoV-2 virus causes large-scale inflammation in the body of certain people, which results in the lungs flooding with fluid, vital organs shutting down, and the possibility of death.

    The starting point for the cytokine storm in the cell is the 'inflammasome'. There are different inflammasomes - the one involved in COVID is called NLRP3.

    Imagine inflammasomes like flat-pack furniture. They can be assembled in just 10 minutes if your cells are damaged or detect danger. 

    Once assembled and activated, they trigger an inflammation cascade that, in some people, can be hard to stop and can overwhelm the body.

    The good news is that new research shows that certain nutrients and botanicals can 'down-regulate' the NLRP3 inflammasome and make it less likely to 'overreact' when the body is exposed to the SarsCoV-2 virus. This means less chance of a cytokine storm.

    What are some risks associated with the NLRP3 inflammasome?

    NLRP3 inflammasome activity is responsible for pneumonia, sepsis and acute respiratory distress syndrome (ARDS) - as seen in COVID.

    NLRP3 inflammasome activation has also been linked to diseases not usually associated with infections, such as Alzheimer’s, Type 2 diabetes, autoimmune diseases and atherosclerosis.

    What are the bioactives that down-regulate the NLRP3 inflammasome? 

    Metagenics Immune Active contains almost all these bioactives in 1 pill! You'd just need to add Vitamin D3 (1000iu - 5000iu per day depending on your blood levels) and SPM's (SPM's are only for if you have COVID or trying to reduce existing inflammation).

    This formulation makes it much easier to take these bioactives than trying to round up all the single versions and swallow lots of pills daily.

    • 150 mg EGCG (as decaffeinated+ green tea leaf extract) per serving. EGCG is categorized as a flavonoid polyphenol, a compound typically found in plants. Polyphenols can help promote antioxidant processes in the body.

    • NAC (N-Acetyl Cysteine) is a metabolite of the sulphur-containing amino acid cysteine. NAC stimulates the biosynthesis of glutathione, a key antioxidant produced in the body. Glutathione plays an important role in protecting the body against oxidative stress and supporting healthy liver detoxification processes.

    • Quercetin is a polyphenolic flavonoid substance present in a variety of plant foods. Quercetin helps protect cells from harmful free radicals. Preclinical studies demonstrate that quercetin affects immunity by acting on leukocytes and other immune cells.

    Serving Size: 1 Capsule  
    60 Capsules  
    Ingredients Amount Per Serving
    Vitamin C (as ascorbic acid) 200 mg
    Zinc (as zinc glycinate) 30 mg
    N-Acetylcysteine 600 mg
    Decaffeinated†† Green Tea (Camellia sinensis) Leaf Extract [standardized to 60% 375 mg
    (225 mg) catechins and 40% (150 mg) epigallocatechin gallate (EGCG)]  
    Quercetin 250 mg
    Other Ingredient
    • Capsule (hydroxypropylmethylcellulose), magnesium stearate (vegetable), and silica
    • This product is non-GMO and gluten-free
    • Take two (2) capsules daily or as directed by your healthcare practitioner. 

    Your personlised health roadmap

    Take the guesswork out of your chronic illness and improve your life dramatically. With your unique genetically-determined nutrition, supplement, environment and lifestyle adjustments, you’ll soon feel empowered and in control of your health from your DNA up!

    You are unique & complex

    Whether you want to optimise your well-being, prevent chronic illness, delay ageing or up your game in sports, the 3X4 DNA test provides the clues you’ve been missing and empowers you to take care of your health in a way that is personalised and precise.

    Why is this DNA test different?

    • 3X4 Genetics makes complex science simple.
    • The test reads your genetic data and translates it into an easy-to-understand personlised action plan.
    • It looks at gene relationships and metabolic pathways which is more medically accurate than just looking at gene variations separately. 
    • The 3X4 DNA test is an industry leader. Based on 20+ years of scientific research and clinical practice, it looks at over 160 genes in 36 metabolic pathways to help you understand your body’s unique needs, so that you can personalize your diet and lifestyle decisions for a longer, healthier and better life.

    Understanding the root cause of chronic disease


    More and more research is showing that your genes interact with each other, and with your nutrition, environment and lifestyle choices.

    How and what you eat, your exposures to environmental toxins, how you move and sleep, your stress levels, your mental, emotional and spiritual experiences, your traumas, all affect how our genes behave.

    Your genes, which carry the instructions that tell your body how to build, regulate and maintain itself, also tell your body how to respond to the food, toxins, exercise, stress, sleep, and anything else that your body is exposed to. 

    It's a two-way relationship. Understanding more about your genes helps you personalise your health choices to keep yourself as healthy as possible.

    We now know from research, that the body functions as a whole and that the body systems talk to each other. For example, your gut health can affect your brain health; and your brain health, your gut.

    The cells in your gut lining produce neurotransmitters such as serotonin that make you feel happy; and stressful thoughts can make your gut tight or churn. 

    Because of this, 3X4 genetics believes it's very useful to look at the body at the level of cells, pathways and systems.


    Your body is made up of complex, interconnected cells, pathways and systems so the 3X4 Genetic test groups your genes into these headings.


    We are the sum of our cells, and we're only as healthy as they are. Imagine your body as Pleasantville and every cell in your body as a house. All the houses in the town function independently. 

    Each household needs to takes care of its own day-to-day maintenance and business, but ultimately contributes to the overall success and functioning of the town. 

    Similarly, every cell in your body has its own mechanisms to function, clean and protect itself. Your cells know what to do because your genes tell them what to do. If your genes have a misspelling, its instructions will be slightly less effective.

    Knowing your genetic variations and then compensating for and supporting them with personalised healthy choices, can help prevent, delay and/or reverse chronic disease, at a cellular level.


    3X4 Genetics believes in going 'upstream', like a detective, to better understand the root cause of symptoms.

    To explain this, imagine a river. Certain streams feed into this river. The health of the river depends on the health of the streams further up the hill. All the streams need to be healthy and functioning properly for the river to function properly.

    If just one river is not functioning optimally, it will affect the quality of the river's water and the symptoms will be seen as sick plants, animals and households along the river.

    Certain genes function in specific pathways like a cascade. If you don't find a variation in one gene in one pathway, keep looking further up the pathway, or in related pathways, for genetic variations that you need to help with more personlised health choices to function better. This will improve the functioning of the whole pathway.


    Additional sections this test looks at are Energy, Activity and Nutrients. These categories provide useful information about how you gain and lose weight, your resting metabolism, your appetite, a possible predisposition to wanting to snack because you never feel full, whether exercise or dieting will be more useful for weight loss, how your circadian rhythms may affect your appetite, and more.

    Meet the scientist behind the test

    In her role as Chief Science Officer, Dr Yael Joffe brings over 20 years of experience in nutrition, genetics, sound research, clinical practice and scientific integrity to 3X4.

    In the rapidly-evolving discipline of nutrigenomics, Yael is globally acknowledged as a leading expert in the field. She is a highly sought-after speaker, has co-authored two books, ‘It’s Not Just Your Genes’ and ‘Genes To Plate’, and has been published in multiple peer-reviewed scientific journals.

    Yael is at the forefront of nutrigenomic education and has helped develop and supervise nutrigenomics courses around the world, including her own Manuka courses, which have trained hundreds of healthcare practitioners globally.

    She is currently an Adjunct Professor, teaching Nutrigenomics at Rutgers University and MUIH.

    The Report

    • The report is a practical, action plan of clear, summarised recommendations
    • Offers personalised nutrition, environment, lifestyle and behaviour recommendations
    • Helps you make both big and small health choice changes 
    • 82 gene variants are analysed and grouped into 25 metabolic pathways under 5 main biological headings 
    • This pathway-based analysis of related genes in their metabolic pathways is more medically correct and useful than looking at single genes not show in their pathways which is used by many other genetic tests
    • Uses colours and pictures so both you and your healthcare practitioner can easily understand your results
    • The colours help you quickly see where you need to prioritise and focus your health efforts
    • Contains a glossary where all 25 pathways are defined and explained in simple, easy-to-understand language


    Click here to see what you'll get in your 3X4 Report:

    3X4 Sample Report | Female

    3X4 Sample Report | Male

    Report categories

    1. Cellular
    2. Systems
    3. Energy
    4. Activity
    5. Nutrients

    • Detoxification
    • DNA damage
    • Inflammation
    • Methylation
    • Oxidative stress
    2. SYSTEMS
    • Blood clotting
    • Bone/Collagen/Joints
    • Brain health
    • Glucose and Insulin
    • Sex hormone balance
    • Vascular health 
    3. ENERGY
    • Adipogenesis
    • Appetite/Satiety/Intake
    • Energy expenditure
    • Exercise Response
    • Pro-inflammatory fat
    • Weight gain & loss of resistance
    • Endurance
    • Injury
    • Power
    • Recovery
    • Caffeine
    • Salt
    • Vitamin D

    Price includes

    • 1 x Test kit
    • Delivery of the kit to and from your house
    • Processing of your DNA sample
    • Your DNA report
    • 1 hour feedback consult with Dr Heidi

    How to order your test

    • Email me your first name, surname, cell, and delivery address.
    • I will place your test order with the 3X4 lab.
    • You will receive an email from the lab containing a payment link.
    • Once you've made payment, your DNA test kit will then be couriered to your door.
    • Read the instructions 'How do I do the test?' below.
    • Please call/WhatsApp/email me at any stage of this process if you have questions: 083 382 1300 | 

    How to do the test


    • The easy-to-use 3X4 Genetics test kit comes with step-by-step instructions so you can easily do the test yourself. 
    • No spitting, no needles and no blood.
    • Collecting your genetic sample is as easy as swabbing each cheek for 60 seconds.


    Registering your test kit ensures that the lab correctly connects your genetic data to you.

    1. Complete this step carefully. A complete and accurate sample registration is part of keeping your data safe. If you send your kit back without registering it, your sample will be delayed and possibly discarded.
    2. There's a QR code on the top of your test kit. Open your camera and aim it at the QR code - no need to press the camera button to take a photo. 
    3. yellow link will appear on your camera screen. Click on the link. 
    4. You'll be taken to a simple registration page. Enter all your details and collection address.
    5. Alternately go to and enter your sample ID (it starts with KZA___)


    Now for the exciting part! Once you have registered, it’s time to collect your sample.

    Genetic testing is a complex process. A great quality sample and proper kit registration are the foundations of a quick and easy testing process. If your sample is contaminated, or you don't get enough cells onto the swab, the lab will not be able to process your sample. They'll need to send you another kit and you'll have to resubmit your sample. All this extends the time before you can get your report.

    Here’s how to ensure the best sample possible.

    1. The best time to collect your sample is first thing in the morningimmediately after you wake up and before brushing your teeth.
    2. Do not eatdrinkchew gumbrush your teeth, or smoke 60 minutes before collecting. 
    3. Avoid wearing lip balm or lip stick before or during sample collection. 

    1. Clearly write your date of birth on the vial. Place the vial standing up, on a flat surface. Unscrew the vial cap.

    2. Pull the swab stick out slowly, being careful not to touch the swab tip with anything other than your inner cheek. Don't let the swab touch your fingers or lips. If the swab tip touches anything other than your inner cheek, please request another kit and repeat the test. Rub the swab tip firmly against the inside of your cheek for 60 seconds on each side. Do not rub so hard that you draw bloodbut firmly enough to ensure some inner cheek cells rub off onto the swab. Some samples need to be redone because the person didn't rub hard enough to ensure enough cheek cells get onto the swab. Rotate the swab tip so you can make sure to cover the entire swab with cheek cells. Avoid touching your teeth with the swab tip. 

    3. Pick up the vial and hold it steady in one hand. Slowly insert and twist your swab into the vial. Apply pressure using a corkscrew motion. Push all the way to the bottom of the vial.

    4. Hold the vial steady and move the swab up and down rapidly inside the tube 10-15 times without moving the swab out of the liquid.

    5. Hold the vial firmly and remove the swab by slowly twisting it out with a corkscrew motion. Dispose of the swab.

    6. Replace the vial cap tightly and seal it in the included ziplock bag. Place it back into the 3X4 packaging tube.

    7.  Your sample is stable at room temperature.

    8.Store your sample out of direct sunlight.

    STEP 3: SEND

    Now the final step!Time to send your sample back to the lab.

    1. After you have successfully registered your sample, 3X4 will book a courier collection within 24 hours.
    2. The courier will usually collect in the afternoons within 1-3 days, and will supply a bag and waybill.
    3. Ensure that your sample is ready for collection, and that someone is available to give the parcel to the courier.
    4. Ensure the person who will be answering the door is aware that the collection is taking place.


    Please contact Dr Heidi or the 3X4 Genetics Lab


    • Your 3X4 Genetics report will take about 3 weeks from the date your DNA sample was collected.


    • When your 3X4 Genetics report is ready, I'll contact you to setup up a time for your feedback session.


    • The 3X4 Genetics Lab ensures that the highest standards are maintained when processing your DNA.
    • Their lab is ISO 17025:2005 and ISO 15189:2012 accredited, ensuring that your DNA is managed under rigorous control throughout the whole process.


    • From the time your sample is collected, your DNA and data are kept securely and anonymously in the secure Amazon Web cloud environment.
    • 3X4 ensures that they meet the exacting requirements of POPI, GDPR and HIPAA.
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